ABSTRACT
To find out the Modified Marsh type of celiac disease [CD] patients on histopathological examination of duodenal [D2] biopsies and to correlate it with tissue transglutaminase IgA levels. Cross sectional study. Place of Histopathology laboratory [Department of Pathology], Isra University Hospital and Asian Institute of Medical Sciences [AIMS], Hyderabad. July 2013 to December 2013. 96 patients with a history of malabsorption or atypical symptoms with clinical suspicion of CD were subjected to endoscopy. Endoscopic duodenal [D2] biopsies were taken regardless of age and gender. D2 biopsies were processed for histopathological examination under light microscopy. Out of 96 patients, 45 [46.9%] patients had moderate type of lamina propria inflammation along with highly significant p-value [0.0001].CD type 3a was observed in 34 patients [35.4%]. In this study the comparison of serological level of tissue Transglutaminase IgA [tTGA] and histological severity revealed significant correlation. All Modified Marsh types of CD with tTGA level seen in our study were highly significant [p-value 0.001]. In this study strong correlation was observed between the serological tTGA level and histological findings by Modified Marsh classification along with lamina propria inflammation of duodenal mucosa in CD patients
ABSTRACT
To determine the changes in the serum insulin levels in alloxan induced diabetic albino rats in comparison with oral hypoglycemic drugs. An experimental study. This study was conducted at Al Tibri Medical College Karachi during December 2012 to December 2013. The present study was conducted on 60 Albino rats which were group from A to F consisting of 10 rats in each group. These groups were further divided into two sub groups which were treated with low dose and high dose of the cinnamon and oral hypoglycemic drugs. The results showed that there is significant reduction in serum insulin level in the alloxan treated group animals which was improved in group C animals treated with low dose of cinnamon extract in alloxan induced diabetic rats. Also animals in group D and group E treated with tolbutamide and acarbose respectively showed higher increase in serum insulin level as compared with cinnamon extract treated groups, however when cinnamon extract was used in combination with tolbutamide or acarbose it showed synergetic effects. Tolbutamide and Acarbose treated groups showed better anti diabetic effect by increasing the serum insulin level in comparison with cinnamon extract treated groups when used individually. This effect was enhanced when cinnamon extract was used in combination with either tolbutamide or acarbose